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KMID : 0043319960190060581
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Archives of Pharmacal Research
1996 Volume.19 No. 6 p.581 ~ p.585
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Studies on the Synthesis of Naphthoquinoids-1 : Formal Total Synthesis of (+)-6-Oxo-3,4,4a,5-tetra hydro-3-hydroxy-2,2-dimethylnaphtho-1,2-pyran
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Park Oee-Sook
Lim Jae-Gyeong
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Abstract
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A new formal total synthesis of (+)-6-oxo-3, 4, 4a, 5-tetrahydro-3-hydroxy-2, 2-dimenthylnaphtho-1, 2-pyran (1) which has been known to have bactericidal, bacteriostatic, fungicidal, fungistatic activities against Staphylococcus aureus and other microorganism, is described. The key reaction involves enantioselective prenylation of .alpha.-tetralone via chiral lithioenamine.
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KEYWORD
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(+)-6-Oxo-3, 4, 4a, 5-terahydro-3-hydroxy-2, 2-dimethylnaphtho-1, 2-pyran, Lippia sidoids Cham (verbenzaceae), Bactericidal, Fungicidal acitivtiy, Staphylococcus arureus, Formal total synthesis, Enantioselective, prenylation of -tetralone, lsocatalponol
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